Mechanistic impact of fibrosis by parathyroid hormone excess

The fibrotic impact of parathyroid hormone (PTH) excess is an important aspect primary hyperparathyroidism (PHPT) that can contribute to organ dysfunction and morbidity. Understanding the underlying mechanisms PTH-induced fibrosis identifying potential therapeutic targets may pave way for novel treatment strategies. Further research needed elucidate complex interactions between PTH pathways evaluate efficacy targeted interventions in preventing or reversing associated with PHPT. observed across multiple systems. Fibrosis resulting from impair function lead significant morbidity mortality. involved crucial developing therapies mitigate its detrimental effects.